A forensic excavation at the site of the former Mother and Baby Home in Tuam is expected to get under way later this year.
The Children's Minister has published the Institutional Burials Bill, which provides a lawful basis for excavation, recovery and analysis of remains at the site.
The Government says while the process will be extremely complex due to the number and age of children interred there, it will be carried out by professionals, in line with international standards.
Minister Roderic O'Gorman says every effort will be made to identify the remains.