Over 200 medicines are now unavailable to Irish patients, which includes treatment for chest infections, strep-throat, pneumonia and blood pressure.
The analysis compiled by industry experts also found 11 of these medicines are deemed critical by the World Health Organisation.
The analysis carried out by A-zure Pharmaceuticals found penicillin-based antibiotics used to treat bacterial infections are currently 'unavailable from any supplier or source' in Ireland.
It included Amoxicillin and Penicillin, as well as Cef-a-lexin - an anti-biotic commonly used to treat respiratory infections.
The analysis based on data from the HP-RA also showed a major shortage of over-the-counter cough syrups for both adults and children, Sprays for sore throats, dissolvable paracetamol powder, and aspirin.
In total, 212 medicines are currently unavailable in the country - up from 25 month.
40 per cent the over 200 medicines currently out of stock were found to have just one supplier.
