A part of the N4 between Boyle and Carrick-on-Shannon has been closed due a serious two car crash.
Emergency services are currently at the scene, which is near the turn for Ardcarne Garden Centre.
It's believed at least one person has been taken to Sligo University Hospital.
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Diversions are in place via Knockvicar and Ardcarne.
An examination of the scene is being carried out and drivers are being urged to avoid the area.
The road is due to reopen at around 7pm.