Luke McGrath will captain Leinster for Saturday’s meeting with Scrlets, with Tadhg Furling making his first appearance in 12 months.
Max O'Reilly makes his second appearance for the senior team at full back, with Cian Kelleher on the right wing and Dave Kearney on the left wing having recovered from a minor hamstring injury that ruled him out of selection for the Munster game.
Ciarán Frawley and Liam Turner are selected in the centre for Cullen's team with captain McGrath and Harry Byrne the half backs.
In the pack, Peter Dooley and the fit again Tadhg Furlong are the starting props, with James Tracy selected at hooker. It will be Furlong's first game for Leinster Rugby since last January against Benetton.
Ross Molony and Ryan Baird are selected in the second row together, with Josh Murphy, Dan Leavy and Jack Conan completing the pack for Cullen. Leavy has recovered from a minor calf injury.
On the bench, Osborne is in line to make his Leinster Rugby Senior debut should he be introduced.
The former Naas CBS pupil, who has come through the Leinster Rugby club system with Naas and played with the North Midlands side in the Shane Horgan Cup, is normally based down in the Ken Wall Centre of Excellence in Energia Park but has been training with the Senior team in UCD over the last few weeks and is involved in a match day 23 for the first time tomorrow.
Leinster Rugby undertook the latest round of PCR Testing in UCD yesterday with no positive cases of Covid-19 reported.
One player who had been isolating because of close contact with a positive family member reported feeling unwell earlier in the week and was tested outside of Leinster.
He tested positive for Covid-19 and will continue to self-isolate from the group in accordance with HSE guidelines.
Leinster: Max O’Reilly, Cian Kelleher, Liam Turner, Ciarán Frawley, Dave Kearney, Harry Byrne, Luke McGrath (C), Peter Dooley, James Tracy, Tadhg Furlong, Ross Molony, Ryan Baird, Josh Murphy, Dan Leavy, Jack Conan
Replacements: Seán Cronin, Ed Byrne, Tom Clarkson, Jack Dunne, Scott Fardy, Hugh O’Sullivan, David Hawkshaw, Jamie Osborne
Referee: Mike Adamson (SRU)
