Leitrim lost out by a point against Wicklow in the opening round and know they must take something from their visit to Bretland Park.
Hosts Offaly are in a similar boat, having fallen to a two-point loss to Wexford in their first match.
In this four-team group, Wexford and Wicklow are the early pace-setters and a second successive defeat for either Offaly or Leitrim would have serious consequences.
Both sides will look for the win to put themselves in the frame for a knock-out slot, and steer clear of one of the dreaded relegation slots.
Offaly: T Roe, O Whelan, E Nally, N Buckley, M Mann, E Maher, A Kehoe, R Ennis (c), A Gavin Mangan, F Dempsey, E Hand, M Byrne, S Kehoe, E McEvoy, M Daly.
Leitrim: M Monaghan, E Quinn, A Cornyn, S McCartan, C Tyrrell, C Owens (c), C Le Guen, M McGovern, N Tighe, L O’Dowd, M Guckian, E Bruen, R McHugh, L Fox, S Quinn.
Offaly v Leitrim
TG4 All-Ireland IFC Round 2
Sunday June 5
Bretland Park, Clara, throw-in 2pm