Leo Cullen has made a number of changes to the 23 that accounted for Zebre Parma last weekend, as Leinster face Bennetton in the RDS.
Cullen had recalling a number of Irish players that won the summer series in New Zealand.
Garry Ringrose is back in the starting XV and will captain the side. Ringrose will be partnered in the centre by Robbie Henshaw.
Elsewhere in the backs Jimmy O'Brien, Jordan Larmour and Dave Kearney are the back three. Luke McGrath and Ciarán Frawley in the half-backs.
In the pack, Andrew Porter, Dan Sheehan and Michael Ala'alatoa are selected in the front row. While James Ryan partners South African lock Jason Jenkins for the first time behind them.
Finally, it's a completely new back row for Cullen this week, with Ryan Baird, Josh van der Flier and Caelan Doris selected to start.
On the bench Cian Healy is in line to win his 250th cap if introduced.
Leinster
- Jimmy O’Brien
- Jordan Larmour
- Garry Ringrose (C)
- Robbie Henshaw
- Dave Kearney
- Ciarán Frawley
- Luke McGrath
- Andrew Porter
- Dan Sheehan
- Michael Ala’alatoa
- Jason Jenkins
- James Ryan
- Ryan Baird
- Josh van der Flier
- Caelan Doris
Replacements
- Rónan Kelleher
- Ed Byrne
- Cian Healy
- Ross Molony
- Will Connors
- Cormac Foley
- Ross Byrne
- Charlie Ngatai
Leinster v Benetton
RDS Arena
Friday September 23
Kick-off: 7.35pm
Referee: Jaco Peyper (SARU)