New signing RG Snyman makes his Leinster debut against Bennetton in the URC tomorrow.
While Caelan Doris will lead the team for the first time since being named captain over the summer.
There are 12 personnel changes to the starting XV from the side that beat Dragons last Friday. Indeed the three retained players all lined up in a new position.
Jimmy O'Brien switches to the right wing while Jamie Osborne moves into the centre, with Jack Conan shifting to flanker.
Hugo Keenan one of eight Irish internationals to return
Eight Irish internationals return to the starting line-up, including Hugo Keenan, making his first appearance in the 15-man game since reaching the quarter-finals of the Olympic Games with the Irish Sevens team.
James Lowe comes in to complete the back three while Garry Ringrose partners Osborne in the centre.
Jamison Gibson-Park comes back into the team for his second appearance of the season as Ciarán Frawley takes the number 10 shirt.
Andrew Porter, Rónan Kelleher and Tadhg Furlong complete a front row all making their first appearances of the season. Joe McCarthy following up his try-scoring performance of the bench last week to take a starting berth alongside debutant Snyman in the second row.
Josh van der Flier is also drafted into the starting team after coming off the bench against Dragons. Conan and captain Doris completing the pack.
Lee Barron and Michael Milne retain their places on the bench. They are joined by Thomas Clarkson, who started the first two games of the season.
Ryan Baird is set for his first action of the season, with Brian Deeny and Scott Penny completing a 6/2 split on the Leinster bench.
Academy scrum-half Fintan Gunne is set to make his second appearance of the season off the bench. Whereas Ross Byrne provides the cover at out-half after scoring a try in last week's win.
Leinster: 15. Hugo Keenan, 14. Jimmy O’Brien, 13. Garry Ringrose, 12. Jamie Osborne, 11. James Lowe, 10. Ciarán Frawley, 9. Jamison Gibson-Park, 1. Andrew Porter, 2. Rónan Kelleher, 3. Tadhg Furlong, 4. Joe McCarthy, 5. RG Snyman, 6. Jack Conan, 7. Josh van der Flier, 8. Caelan Doris (C)
Replacements: 16. Lee Barron, 17. Michael Milne, 18. Thomas Clarkson, 19. Ryan Baird, 20. Brian Deeny, 21. Fintan Gunne, 22. Ross Byrne, 23. Scott Penny
Leinster v Bennetton
Stadio Comunale di Monigo
Saturday, October 4, Kick-off: 5:15pm
Referee: Craig Evans (WRU)